リハビリ日記０

男性更年期障害治療のためグローミンを陰嚢に塗布していたところ、最近、インキンタムシが出現した。そこでアゾール系抗真菌剤を塗ったところ、塗り始めて２週間強で男性更年期症状が酷くなってきた。その原因は、アゾール系抗真菌剤のテストステロンの生合成阻害によるものと推察される。下の論文を参照されたし。グローミンを塗って治療している場合のインキンタムシ・ぜにタムシのアゾール系薬剤による治療には注意が必要である。
J Steroid Biochem Mol Biol. 1991 Jan;38(1):95-9.
Inhibitory effect of some imidazole antifungal compounds on the synthesis of 16-ene-C19-steroid catalyzed by pig testicular microsomes.
Nakajin S, Takahashi K, Shinoda M.
Department of Biochemistry, Faculty of Pharmaceutical Sciences, Hoshi University, Tokyo, Japan.
The activity of the enzyme (16-ene-C19-steroid synthesizing enzyme) responsible for the conversion of C21-steroids to 16-ene-C19-steroids, which was localized on pig testicular microsomes, was inhibited by some typical imidazole antifungal compounds such as clotrimazole, econazole, miconazole and ketoconazole which are known to be universal inhibitors of cytochrome P-450-dependent enzymes. The 50% inhibitory concentrations of clotrimazole, econazole and miconazole were 0.29, 0.36 and 1.25 microM, respectively for 16-ene-C19-steroid synthesizing enzyme activity. Clotrimazole was the most powerful inhibitor of all the compounds examined, which shows the competitive inhibition for 16-ene-C19-steroid synthesizing enzyme activity. The Ki-value was 0.26 microM for its activity. The degree of the inhibition by these imidazole compounds was very similar to the inhibition of 17 alpha-hydroxylase and C17,20-lyase activities on pig testicular microsomes.
PMID: 1997127 [PubMed - indexed for MEDLINE]